Issue N# 2 - 2013
CANCER
Two cases of primary malignant melanoma of the larynx: A rare pathology
Authors : Chaput B, De Bonnecaze G, Vergez S, Garrido I, Grolleau JL, Benlyazid A. (Toulouse)
Ref. : Rev Laryngol Otol Rhinol. 2013;134,2:105-108.
Article published in french 
Downloadable PDF document french
Summary :
Introduction: Primary malignant melanoma of the larynx is a very rare entity. There are less than sixty cases described in the literature. Through both cases, we describe and discuss the clinical management of melanoma of the larynx. Clinical cases: Two men aged 80 and 61 years were supported for MPL. The tumor was revealed by persistent dysphonia for the first. For the second, it was a second melanoma of laryngeal location. In both cases it was performed a total laryngectomy extended to the first tracheal rings with bilateral lymphadenectomy associated with adjuvant radiotherapy. Discussion: Excision margins with oncological safety are necessary to except a curative surgery. Still controversial, the adjuvant radiotherapy seems to provide a benefit in terms of local control. The place of targeted therapies remains unclear. However, no prognostic factor is currently clearly identified for this disease. Conclusion: Rare tumor, the MPL is associated with a very poor prognosis. Resective surgery followed by adjuvant radiotherapy is for us the treatment of choice.
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